Comparing the Impact of Saturated Fatty acids from Different Dairy Sources on the proteome of High Density Lipoproteins

BackgroundHigh-density lipoproteins (HDL) play different protective roles in the etiology of atherosclerosis. The anti-inflammatory and antioxidant properties of HDL are of particular interest in that regard. Because dietary saturated fatty acids (SFAs) are known to increase HDL-C concentrations, we investigated how consumption of SFAs from different dairy sources modifies HDL functions as reflected by changes in HDL proteomic profile compared to other dietary fats (monounsaturated - MUFAs and polyunsaturated - PUFAs) and a low-fat diet/high carbohydrate diet. MethodsA randomized crossover controlled trial was conducted in 42 men and women with abdominal obesity and relatively low HDL-C. Subjects were assigned to sequences of 5 isoenergetic diets of 4 weeks each (Table): 1) a diet rich in SFA from cheese (CHEESE); a diet rich in SFAs from butter (BUTTER); a diet rich in MUFA; a diet rich in PUFA and a low-fat, high carbohydrate diet (CHO). All foods were provided to the participants during the experimenta...