COMPARISON OF THE INFLUENCE OF DIAZEPAM AND NEW BENZODIAZEPINE DERIVATIVE (BD-1158) ON THE BEHAVIOUR OF RABBITS UNDER SPONTANEOUS CONDITIONS

The purpose of the present study was to compare the activity and side effects of diazepam and new benzodiazepine derivative (BD-1158). The experiments were performed in 2 groups of rabbits. In the first group BD-1158 was administered intraperitoneally at a dose of 10 mg/kg of body weight, diluted in 1% starch solution up to 1 ml. In the second group diazepam was injected intravenously at a dose of 1 mg/kg. The substances were administered 35-40 min before the behaviour recording. It was found that both substances produced similar effects on animal behaviour under physiological conditions. They had a strong anxiolytic and sedative influence and decreased orientation-searching reactions, grooming, and water and feed uptake.