Efeitos da terapia combinada atorvastatina e clopidogrel na biodisponibilidade da estatina e na função plaquetária em pacientes com doença coronária estável

ABSTRACT Effects of the Atorvastatin and ClopidogrelCombination Therapy on Statin Bioavailabilityand Platelet Function of Patients withStable Coronary Disease Background: Atorvastatin 80 mg is recommended in patientswith coronary artery disease to reduce cardiovascularevents, however, there is controversy regarding the phar-macokinetic interactions between high doses of statinsand the concomitant use of clopidogrel, since they share thesame biotransformation pathway. This study evaluated theeffects of the atorvastatin/clopidogrel combination therapyon the pharmacokinetics of statins and on platelet function ofpatients with stable coronary artery disease receivingchronic statins. Method: Patients were admitted four times(V1 to V4) to a day-clinic. Statin was discontinued sevendays (D) before the first admission. Patients then receivedatorvastatin 80 mg (D1 to D22) and clopidogrel 75 mg/day(D8 to D29). Fasting blood samples were obtained at alltime points for lipid measurements, platelet function tests(cone and plate technique), and quantification of atorvastatinplasma levels (liquid chromatography and mass spectrome-try).