L. AvanzinoL. MarinelliA. BuccolieriC. TrompettoG. Abbruzzese Creutzfeldt-Jakob disease presenting as corticobasal degeneration: a neurophysiological study

Creutzfeldt-Jakob disease (CJD) can occasional- ly present with a clinical picture resembling a corticobasal degeneration (CBD). Transcallosal inhibition, as tested by focal transcranial magnetic stimulation, is frequently absent or highly disrupted in CBD patients. We report a case of CJD presenting at the beginning of the disease as a CBD in which the ipsilateral silent period (iSP) was pre- sent and well detectable. This brief report shows that study of the iSP may be a useful diagnostic tool in order to dif- ferentiate CBD from syndromes presenting with similar clinical features.