THE INFLUENCE OF X-RAY IRRADIATION ON CERTAIN PORTIONS OF THE PERIPHERAL SYSTEM IN RATS

Microscopic investigations of nerve fibers and their endings in 25 adult rats subjected to single irradiation in the dose of 2,400 r were conducted. Nerve fibers of the joint sac, atrial septum and the intestinal wall were under study. Staining was performed with silver according to Bilshovsky-Gross in Lavrentiev's modification; in 2 rats methylene blue was employed. In 4 hours following the irradiation morphological phenomena could be revealed, which testify to the state of extreme irradiation. In 24 hours there are fewer changes. They appear again in a large degree upon survival of the animals up to 72 hours. The changes are quite expressive on nerves of the joint sac, and to a lesser degree in the atrial septum; least of all they are marked in the intestinal wall. The changes are not specific. They are noted also after other procedures. In an insignificant number they are observed in normal conditions, undoubtedly, independent of the state of irritation. Only a part of fibers and endings are effected, the other part always remains unchanged. Changes in the joint sac, atrial septum and intestinal wall testify to the fact that there are primary injuries of the nerve tissue. It can be assumedmore » that the morphological changes in fibers and receptors may be manifested in the reception and in conductors of reflex processes, appearing in irradiated tissues. (auth)« less