Variations in the TNFα gene and their interactions with the IL4R and IL10 genes in relation to hand osteoarthritis

Background The development of osteoarthritis (OA) involves inflammation, but the evidence for participation of genes propagating or inhibiting inflammation in the OA process is inconsistent. We investigated the associations of common variants in the TNFα gene, and their interactions with other cytokine genes, with hand OA among Finnish women.