PA01.33. Mode of action of medhya drugs: A review

Purpose: Memory is combination of power of acquisition (Grahan), retention (Dharan) and recollection (Smaran). Vata, pitta, and kapha are the three psychobiological dimensions (energy) or biological rhythms regulating the entire functioning of the human body. Pitta is responsible for understanding and attaining knowledge due to its Satva, Aashukari and Tikshna property. Vata is responsible for association of ideas. Kapha provides stability which is necessary for retention of memory. Several Central Nervous System disorders (CNS) are often associated with impairment in cognitive functions. Disorders of memory can range from mild to severe. It is major health problem of 21st century. Main objective of this work is to understand the ayurvedic aspect of learning and memory mode of action of some medhya drugs W.S.R. Vacha, Shankhpushpi, Endri, Jyotishmati and brahmi. Method: A review on available scientific information in terms of references in classical texts, and Nighantus, chemical constitute, pharmacological activity is prepared with a view to understand mode of action of these Medhya dravya. Result: Pitta is responsible for understanding and attaining knowledge due to its Satva, Aashukari and Tikshna property. Vata is responsible for association of ideas. Kapha provides stability which is necessary for retention of memory. Sheetvirya and improves retention power and ushna virya drugs enhance power of acquiring new information and data interpretation. Conclusion: Ushna virya and sheet virya drugs acts through different mechanism and enhance cognition. It may provide parameters for selection of medhya drug in different memory disorder.