Protection of rat pancreatic islets by potassium channel openers against alloxan, sodium nitroprusside and interleukin-1β mediated suppression—possible involvement of the mitochondrial membrane potential

Mikael Kullin,Zhanchun Li,J. Bondo Hansen,Nils Welsh,F.A. Karlsson,Stellan Sandler

Protection of rat pancreatic islets by potassium channel openers against alloxan, sodium nitroprusside and interleukin-1β mediated suppression—possible involvement of the mitochondrial membrane potential

2003

Mikael Kullin
Zhanchun Li
J. Bondo Hansen
Nils Welsh
F.A. Karlsson
Stellan Sandler

Aims/hypothesis We aimed to study the effects of two KATP channel openers (KCO), diazoxide and the more potent compound NNC 55-0118, on beta-cell suppression and/or toxicity induced by alloxan, sodium nitroprusside and IL-1β.

Keywords:

Potassium channel
Membrane potential
Endocrinology
Internal medicine
Sodium nitroprusside
Interleukin
Potassium channel opener
Pancreatic islets
Alloxan
Biology
Biochemistry
Diazoxide
Nitric oxide

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