Epigenetic modulation by biosynthetic nanomaterials from plants in cancer

Abstract The development of environment-friendly technologies in material synthesis is of substantial significance to explore their biological applications. Nowadays, plant extracts have been widely used to synthesize a variety of inorganic nanoparticles with well-defined characteristics such as chemical composition, size, and morphology. Their implementations in many leading-edge technological areas have been investigated due to its rapid and easily scale-up technology. Among various nanomaterials those produced by medicinal plants have been reported more pharmacologically active than those chemically synthesized. Epigenetic dysregulation is strongly linked with cancer. As epigenetics alteration covers heritable yet reversible changes in DNA and histone modifications that regulate gene regulation, these biologically synthesized nanoparticles are seen to play important role in epigenetic modification. In this review we will be studying the epigenetic aspect of biosynthesized nanoparticles from plant and asses their therapeutic mechanism in cancer.