Effect of bladder preserving surgery combined with internal iliac artery infusion chemotherapy for the treatment of muscle invasive bladder cancer

Objectives To investigate the clinical effect of adjuvant internal iliac artery infusion in patients with muscle invasive bladder cancer after resection of bladder tumor. Methods 84 patients with muscle invasive bladder cancer who refused to accept or not accept bladder resection were selected as the object of study from January 2012 to January 2015 in the hospital. All patients underwent transurethral resection of bladder tumor(TURBT), who were divided into two groups after operation, the control group (40 cases with systemic chemotherapy), the experimental group (44 cases with internal iliac artery infusion chemotherapy). Bladder retention rate, adverse drug reaction, HIF - 1 alpha, VEGF positive rate and 3-year survival rate were compared between the two groups. Results The positive rate of the patients in the two groups decreased significantly after treatment and experimental group of HIF - 1 alpha and VEGF positive rate was 45.5%, 36.4%, significantly lower than control group of 65.0% and 52.5%, there was statistically significant difference between the two groups(P<0.05). In the control group, the incidence of complications was 45.0%, the experimental group complications occurrence rate was 25.0%, the difference between the two groups were obvious(P<0.05).1-year follow-up of bladder retention rate of the control group was 60.0% and the experimental group was 81.8%, the difference was statistically significant(P<0.05). 3-year survival rate of the experimental group was 70.5%, and the control group was 52.5%, there was statistical significance difference between the two groups(P<0.05). Conclusions The effect of internal iliac artery infusion chemotherapy in patients with muscle invasive bladder cancer is better, and it is suitable for clinical promotion. Key words: Bladder Neoplasms; Electrosurgery; Infusion