Evaluation of cytotoxic effects and antimicrobial activities of Lecaniodiscus cupanioides (Planch.) leaf extract

The present study assessed the cytotoxic and antimicrobial activities of Lecaniodicus cupanioides leaf extract, evaluated its killing rate and also determined the presence of certain phytochemicals. The antimicrobial activities were assessed via a susceptibility test and by determination of minimum bacteriotastic and bactericidal concentrations. The killing rate was evaluated at regular intervals over a 2h-period under different concentrations and the cytotoxicity was measured through a brine shrimp lethality test. Zones of inhibition exhibited by the extract at 20 mg/ml ranged between 20±0.00 and 23±0.58 mm against both bacteria and yeast isolates. The minimum inhibitory concentrations (MICs) were between 1.25 and 2.50 mg/ml against bacteria and 0.63 and 1.25 mg/ml against yeasts. The minimum bactericidal concentrations (MBCs) ranged from 2.50 to 5.00 mg/ml (bacteria) and 1.25 to 2.5 mg/ml (yeasts). At a concentration of 1×MIC after 15 min of contact time, the mortality against Shigella sonnei (ATCC 2993...