Polymorphisms of UGT1A9 and UGT2B7 influence the pharmacokinetics of mycophenolic acid after a single oral dose in healthy Chinese volunteers

Dong Guo,Liang-Fang Pang,Yang Han,Hong Yang,Guo Wang,Zhi-Rong Tan,Wei Zhang,Hong-Hao Zhou

Polymorphisms of UGT1A9 and UGT2B7 influence the pharmacokinetics of mycophenolic acid after a single oral dose in healthy Chinese volunteers

2013

Dong Guo
Liang-Fang Pang
Yang Han
Hong Yang
Guo Wang
Zhi-Rong Tan
Wei Zhang
Hong-Hao Zhou

Purpose To explore the impact of UDP-glucuronosyltransferase polymorphisms (UGT1A9-118(dT) 9/10 , UGT1A9 CI399T, UGT1A9 C-440T and UGT2B7 G211T) on the pharmacokinetics of mycophenolic acid (MPA) in healthy Chinese volunteers.

Keywords:

Anesthesia
UGT2B7
Medicine
Pharmacology
Mycophenolic acid
Pharmacokinetics
pharmacology toxicology
Diabetes mellitus
single oral dose

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