Chemical carcinogenesis : models and mechanisms

Section I Xenobiotics: Metabolism and Interaction with Cellular Macromolecules.- Cytochrome P-450 Function Analyses with Monoclonal Antibodies and cDNA Expression Vectors.- Cytochromes P-450 as Determinants of Susceptibility to Carcinogenesis by Aromatic Amines and Nitroaromatic Hydrocarbons.- Species-Dependent Differences in the Metabolic Activation of Polycyclic Aromatic Hydrocarbons in Cells in Culture.- Complex Metabolic Activation Pathways of Polycyclic Aromatic Hydrocarbons: 3-Hydroxy-trans-7,8-Dihydroxy-7,8-Dihydrobenzo[a]-pyrene as a Proximate Mutagen of 3-Hydroxybenzo[a]pyrene.- Carcinogenicity of Methyl Halides: Current Problems Concerning Chloromethane.- Relationship Between Structure and Mutagenic/Carcinogenic Activity of Short Chain Aliphatic Halocompounds: A Collaborative Project.- Enzymatic Detoxication of Tumorigenic Bay-Region Diol-Epoxides of Polycyclic Aromatic Hydrocarbons by Conjugation with Glutathione.- Antigenotoxic and Anticarcinogenic Effects of Thiols. In Vitro Inhibition of the Mutagenicity of Drug Nitrosation Products and Protection of Rat Liver ADP-Ribosyl Transferase Activity.- Relationships between NADPH Content and Benzo(a)pyrene Metabolism in Normal and Glucose-6-Phosphate Dehydrogenase-Deficient Human Fibroblasts.- Comparison of the Covalent Binding of Various Chloroethanes with Nucleic Acids.- In Situ Detection of Hepatic AF-DNA Adduct Formation During Continuous Feeding of 0.02% Acetylaminofluorene and in Enzyme-Altered Foci Induced by Four Different Protocols.- Interaction of Activated N-Nitrosamines with DNA.- Antibodies Specific for DNA Components Modified by Chemical Carcinogens and Their Binding Efficiency to DNA Modified in Vivo and in Vitro with the Corresponding Carcinogens.- Liver DNA Dammage by Chemical Carcinogens: Role of Thyroid Hormones.- Activation of Urinary Bladder Carcinogens within the Target Organ.- Lipid Peroxidation and Bioactivation of Halogenated Hydrocarbons in Rat Liver Mitochondria During Experimental Siderosis.- Lipid Peroxidation, Protein Thiols, Calcium Homeostasis and Imbalance of Antioxidant Systems in Bromobenzene Induced Liver Damage.- Section II Developmental Stages of Carcinogenesis.- Cell Proliferation and Cell Loss in Progression in Liver Carcinogenesis: A New Hypothesis.- Human Papillomavirus 16 DNA and Epithelial Cell Immortalization.- Cellular and Molecular Studies of Growth, Differentiation and Neoplastic Transformation of Human Bronchial Epithelial Cells in Vitro.- New Insights into Tumor Promotion from Molecular Studies of Protein Kinase C.- Model Studies on the in Vitro Activation of c-Ha-ras Protooncogene by Dietary Components.- DNA Fragmentation or Changes in Chromatin Conformation. Results with Two Model Systems: Promotion in Rat Liver Carcinogenesis and Proliferation in Mastocytes.- Cellular and Molecular Changes in Early Stages of Hepatocarcinogenesis.- Sequential Phenotypic Conversion of Renal Epithelial Cells During Neoplastic Development.- The Wound Response as a Key Element for an Understanding of Multistage Carcinogenesis in Skin.- Possible Mechanism of Orotic Acid Induced Liver Tumor Promotion in the Rat.- The Role of Initiating and Promoting Properties in Aromatic Amine Carcinogenesis.- Long-Term Fate of the Hepatocyte Hyperplastic Foci Induced by a Two Stage Carcinogenetic Protocol.- Effects of Chronic Thioacetamide Administration on Liver Drug Metabolizing System and on the Development of Hepatocyte Foci, Nodules and Tumors.- Cell Death by Apoptosis in Normal, Preneoplastic and Neoplastic Tissue.- Role of Cell Death for Growth and Regression of Hormone-Dependent H-301 Hamster Kidney Tumors.- Can Apoptosis Influence Initiation of Chemical Hepatocarcinogenesis?.- Analysis of the Biology of Initiation Using the Resistant Hepatocyte Model.- Theoretical Calculations of the Electrostatic Potential of Some Tumor Promoters.- A Cell Culture Model for Study of Chemically-Derived and Spontaneous Mouse Lung Alveologenic Carcinoma.- Studies on Metabolic Perturbations and Tumor Promotion: Glycine Induces the Synthesis of Orotic Acid, a Tumor Promoter and the Expression of Certain Cell Cycle Dependent Genes.- Comparative Study on the Effect of Different Treatment Schedules on Some Carbohydrate Metabolizing Enzyme Activities in Rats During Hepatocarcinogenesis.- Expression of a Novel N-Acetylglucosaminyltransferase in Rat Hepatic Nodules.- Cytosolic and Plasmamembranes Enzymatic Activities During Diethylnitrosamine-Induced Carcinogenesis in Rat Liver.- Chemoprevention of Experimental Tumorigenesis by Dehydroepiandrosterone and Structural Analogs.- Inhibition of Initiation and Promotion Steps of Carcinogenesis by Glucose-6-Phosphate Dehydrogenase Deficiency.- Additive Effect of Low-Dose Diethylnitrosamine on the Initiation of Liver Carconogenesis in Rats.- Modulation of Liver Carcinogenesis by Surgery.- Analysis of the Effects of Modifying Agents on Six Different Phenotypes in Preneoplastic Foci in the Liver in Medium-Term Bioassay Model in Rats.- S-Adenosylmethionine Antipromotion and Antiprogression Effect in Hepatocarcinogenesis. Its Association with Inhibition of Gene Expression.- Development and Application of an in Vivo Medium-Term Bioassay System for the Screening of Hepatocarcinogens and Inhibiting Agents of Hepatocarcinogenesis.- Section III Regulation of Cell Growth in Chemical Carcinogenesis.- Nuclear Alterations in Liver Carcinogenesis: The Role of Non-Polyploidizing Growth.- Growth Control of Hepatocytes in Primary Culture and Its Aberration in Carcinogenesis.- Constitutive and Induced Expression of Heat Shock Proteins During Liver Carcinogenesis and in Hepatomas.- Regulation of S-Adenosyl-L-Methionine Decarboxylase in Normal and Regenerating Rat Liver by Adenosine-Containing Molecules.- Derangements of Cationic Amino Acid Transport in Fibroblasts from Human Desmoid Tumor.- Lipids as Effectors and Mediators in Growth Control of Ascites Tumor Cells.- Susceptibility of grc-Bearing Rats to DEN and Its Relationship to the HMP Pathway.- Lipoproteins, Cell Proliferation and Cancer.- A Mechanistic Association Between Cholesterol Metabolism and Cell Proliferation.- Modifying Influence of Fasting on DNA Synthesis, Cholesterol Metabolism and HMP Shunt Enzymes in Liver Hyperplasia Induced by Lead Nitrate.- Regulation of Protein Degradation in Neoplastic Cells.- Proteolysis Associated with Thymidine-Induced Selective Cell Death in L-Cell Cultures.- Role of Intermediate Filaments and Ubiquitin in Protein Catabolism in Tumor Cells.- Section IV Nutritional Carcinogenesis and Anticarcinogenesis.- The Choline-Devoid Diet Model of Hepatocarcinogenesis in the Rat.- Methyl Insufficiency in Carcinogensis.- Choline Deficiency, Lipid Peroxidation, Liver Cell Surface Receptor Alterations and Liver Tumor Promotion.- Mechanism of Initiation of Liver Carcinogenesis by Dietary Imbalance.- Modulation by Polyunsaturated Lipid Diets of Nitrosamine-Induced Cancers in Rats: Effects on Prooxidant State and Drug Metabolism.- Lipids and Colonic Carcinogenesis. Fact or Artefact?.- Section V Mechanisms in Human Carcinogeneis.- Mechanisms of Endogenous Nitrosation.- The Role of N-Nitroso Compounds in Human Cancer.- Models for Combined Action of Alcohol and Tobacco on Risk of Cancer: What Do We Really Know from Epidemiological Studies?.- Epidemiological Approach to the Investigation of Mechanisms of Action in Human Bladder Carcinogenesis.- Concluding Remarks.