Gain of 1q is a potential univariate negative prognostic marker for survival in medulloblastoma

Purpose: Tumor risk stratification during diagnosis is paramount for children with medulloblastomas, primarily because very young patients ( Experimental Design: Array-based comparative genomic hybridization (aCGH) was used to identify chromosomal copy number abnormalities in a cohort of 49 medulloblastoma tumors. Based on the karyotypes generated from aCGH analysis, each tumor was scored for copy number abnormalities, and the log-rank test was used to evaluate whether any cytogenetic events were associated with survival. Results: A single copy gain of 1q was shown to be a negative prognostic marker for survival in medulloblastomas with high statistical significance ( P Conclusion: A gain of 1q provides a potential means of predicting overall survival in medulloblastoma.