Impact of Kuntai Capsules on LIF, IGF-1 and EGF Expression in the Implantation Window of Endometrium in Mice

Objective: This study aims to investigate the influence of Kuntai capsules on the expression level of leukemia inhibitory factor (LIF), insulin-like growth factor-I (IGF-1) and epidermal growth factor (EGF) during the mouse implantation window of superovulation period and controlled ovarian hyperstimulation period. Methods: A total of 90 female mice were randomly divided into six groups (n=15, each group). The RNA expression of EGF, LIF and IGF-1 in the endometrium on the 4th day of pregnancy was detected using the fluorescence quantitative PCR method, and the relative expression of these three factors in each group was compared. Results: The mRNA expression of these three factors in the endometrium during the mouse implantation window period was significantly lower in the superovulation group and COH group than in the control group (P