Substituted piperidine derivatives with antipsychotic 4- (1H-indolyl-1-yl) -1.

THE present invention relates to compounds of formula (I), their pharmaceutically acceptable addition salts and stereochemically isomeric forms thereof, wherein the dotted line represents an optional bond; R SUP {1} {SUP YR, 2} are independently hydrogen, halogen, C SUB {1-6} {SUB ALKYL OC 1-6 alkyloxy}, {SUP R, 3} {SUP YR, 4} ARE independently hydrogen, C SUB {1-6} alkyl, phenyl or substituted phenyl with one, two or three substituents selected from halo, hydroxy, nitro, cyano, trifluoromethyl, C SUB {1-6} alkyl, C {SUB , 16} alkyloxy, C SUB {1-6} alkylthio, mercapto, amino, mono and di (C SUB {1-6} alkyl) C SUB {1-6} alkylcarbonyl; Alk is C SUB {14} alkanediyl; D is a pyrimidinone, piperidone OR A BENCIMIDOZOLIDINONA; PRESENTING antipsychotic activity; Their preparation, compositions containing them and their use as medicaments.