Protein-Nukleinsäure-Interaktionen im Massenspektrometer

Protein-nucleic acid complexes play a significant role in all DNA- and RNA-related cellular processes. The identification of protein-nucleic acid interaction sites is important to understand the structure, function and regulation of these complexes. Here, new approaches in mass spectrometry using UV-induced cross-linking of nucleic acids with proteins have recently proven as an important technique to not only identify proteins but specific regions of proteins that interact with RNA or DNA.