MDRD or CKD-EPI for glomerular filtration rate estimation in living kidney donors

Abstract Introduction The evaluation of the measured Glomerular Filtration Rate (mGFR) or estimated Glomerular Filtration Rate (eGFR) is key in the proper assessment of the renal function of potential kidney donors. We aim to study the correlation between glomerular filtration rate estimation equations and the measured methods for determining renal function. Material and methods We analyzed the relationship between baseline GFR values measured by Tc- 99 m-DTPA (diethylene-triamine-pentaacetate) and those estimated by the four-variable Modification of Diet in Renal Disease (MDRD4) and Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations in a series of living donors at our institution. Results We included 64 donors (70.6% females; mean age 48.3 ± 11 years). Baseline creatinine was 0.8 ± 0.1 mg/dl and it was 1.1 ± 0.2 mg/dl one year after donation. The equations underestimated GFR when measured by Tc 99 m-DTPA (MDRD4 – 9.4 ± 25 ml/min, P r  = .41; P r  = .27; P Conclusions In our experience, CKD-EPI is the equation that better correlates with mGFR-Tc 99 m-DTPA when assessing renal function for donor screening purposes.