Dietary patterns and risk of hyperuricemia in general population: results from the TCLSIH Cohort Study

Abstract Objective Prospective cohort studies linking dietary patterns and hyperuricemia (HUA) are limited, especially in Asian populations. This study aimed to prospectively investigate the association between various dietary patterns and risk of HUA in a general adult population. Method We used data from the Tianjin Chronic Low-grade Systemic Inflammation and Health (TCLSIH) Cohort Study of 20,766 men and women who were free from HUA, cancer and cardiovascular disease at baseline. Dietary patterns at baseline were identified with factor analysis based on responses to a validated 81-item food frequency questionnaire. HUA was defined as serum uric acid levels >420 μmol/L in men and >350 μmol/L in women. Cox proportional hazards regression models were used to examine the association of dietary patterns with incident HUA. Results A total of 4,389 first incident cases of HUA occurred during 73,822 person-years of follow-up (median follow-up of 4.2 years). Three main dietary patterns were extracted: vegetable pattern, sweet food pattern, and animal food pattern. After adjusting for demographic characteristics, lifestyle factors, each other dietary pattern scores and inflammatory markers, comparing the highest with the lowest quartiles of dietary pattern scores, the multivariable hazard ratios (95% confidence interval) of HUA were 0.79 (0.72, 0.87) (P for trend Conclusions Dietary patterns rich in animal foods or sweet foods were positively associated with a higher risk of HUA, whereas the vegetable pattern was negatively associated.