Synthesis of Symmetrical N-Aryl-C-phosphonoacetamidines

An efficient synthesis of a series of novel symmetrical N- aryl- C -phosphonoacetamidines through reaction of diisopropyl (chloroethynyl)phosphonate with primary aryl amines was developed. This procedure tolerates a wide range of functional groups and has a good atom economy. The ( E ) - isomer was the major product that crystallized preferentially over the ( Z )-isomer .