Triterpenoids and phenolics from the fruiting bodies of Inonotus hispidus and their activations of melanogenesis and tyrosinase

Abstract Two new 24-methyl lanostane triterpenoids, hispindic acids A and B ( 1 and 2 ), and a new phenolic compound, hispinine ( 7 ), along with nine known compounds ( 3–6 , and 8 – 12 ), were isolated from the fruiting bodies of Inonotus hispidus . Their structures were elucidated based on the extensive analysis of spectroscopic data (NMR and HRMS). Hispindic acid A ( 1 ) possesses an unusual formyl group at C-30. Compounds 1 , 3–4 , and 8 showed stronger activate abilities of melanogenesis and tyrosinase in B16 melanoma cells than those of positive control, 8-methoxypsoralen, at 50 μmol/L.