Absolute Ultrasound Perfusion Parameter Quantification of a Tissue-Mimicking

This study presents three methods for absolute quantification in ultrasound perfusion analysis based on bolus tracking. The first two methods deconvolve the perfusion time sequence with a measured AIF, using a nonparametric or a parametric model of the tissue residue function, respectively. The third method is a simplified approach avoiding deconvolu- tion by assuming a narrow AIF. A phantom with a dialyzer filter as a tissue-mimicking model was used for evaluation. Es- timated mean transit times and blood volumes were compared with the theoretical values. A match with a maximum error of 12% was achieved.