Effect of Relative Molecular Mass of Hydroxyethyl Cellulose on the Preparation of Emamectin Benzoate Microcapsules

Using different viscosity average relative molecular mass of hydroxyethyl cellulose(HEC) as the emulsifier,microcapsules containing emamectin benzoate were prepared by in-situ polymerization.The factors affecting the surface morphology,the particle size and distribution,the encapsulation efficiency and the drug loading were investigated,and the release properties were determined.The results show that the morphology of the microcapsules made by small relative molecular mass HEC is uniform,dense and the microcapsules have no adhesion phenomenon.With the increase of viscosity average relative molecular mass of HEC,the particle size and the size distribution of microcapsules increase,while the encapsulation efficiency and the drug loading decrease.It is showed that the release performances of the microcapsules which prepared by small relative molecular mass HEC are better.