Infant pain response according to vaccine administration

OBJECTIVE: To determine if acute pain response in infants after administration of pentavalent diphtheria (polio, tetanus, acellular pertussis and B Type Hemophilus influenzae: Pentavac) and meningitis C vaccine (NeisVacC) vary according to the administration order. METHOD: A multicenter, randomized control trial, double-blind was performed in three pediatric nursing consultations of three healthcare centers between December 2010, and December 2011. Two months healthy children in subjected to a routine immunization. Routine immunizations are given in a different order to children; first NeisVac C and then Pentavac are given to the Group A and first Pentavac and then NeisVac C are given to the Group B. Was measured infant pain during the injection of the vaccine using a validates method, the Modified Behavioral Pain Scale (MBPS). Parents measured pain with the VAS scale and evaluated the presence of tears before the beginning of vaccination. RESULTS: Within the 184 infants, 92 received the A order, and 92 the B order. There were no differences between groups in terms of sociodemographic characteristics. The average (AV) pain scores per infant after receiving injections were significantly lower when Pentavac was administered in a second place in A Group. MBPS 5.6 (SD 1.5) versus NeisVac C 7.6 (SD 1.3) (p = 0.0001), EVA 3.6 Parents (SD) versus 5.4 (DE 1.9) (p = 0.0001). In B Group, the average for Pentavac" BPS pain was 7.6 (SD 1.5) versus 7.9 (DE 1.2) to NeisVac C Parents EVA 5.5 (SD 1.8) versus 6.3 (SD 1.6) (p = 0.004). CONCLUSIONS: Pain was reduced when Pentavac vaccine was administered before NeisVac C in infants subjected to a routine vaccination. It is recommended that the order of injections of the vaccine will be first Pentavac followed by NeisVac C.