Method for improving drug release in carbon nano tube drug delivery system by displacement object

2011 
The invention discloses a method for improving drug release in a carbon nano tube drug delivery system by a displacement object. Based on a mechanism of loading drugs of a carbon tube cavity, one or a plurality of displacement objects are loaded when the drugs are loaded, the displacement objects can reduce the surface tension of a solution or the acting force of the displacement objects and the carbon nano tube cavity is stronger than the acting force of the drugs and the tube cavity so as to overcome the energy barrier of the drugs released from the carbon nano tube cavity and weaken the acting force between the drugs and the tube cavity, and the purpose of promoting drug release is achieved. After adding the displacement objects promoting release, the 24-hour accumulated release degreeof the drugs is increased to 70-80% with the displacement objects from 10% without the displacement objects. The method solves the problem of drug release in the carbon tube cavity, is simple and feasible, and overcomes the defect of inconvenience in operation because light, heat and other external drives are released on an organism. Because of the improvement of the drug release, a plurality of drugs can be loaded in a tube cavity loading mode, and the application of carbon nano tubes in the drug delivery system can be greatly increased.
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