FORMULATION AND EVALUATION OF CREAM CONTAINING ANTIFUNGAL AGENTS, ANTIBACTERIAL AGENTS AND CORTICOSTEROIDS

Plan: The main aim of our research was to develop a novel cream formulation consisting of combination of Miconazole nitrate, Mupirocin and Hydrocortisone for the treatment of secondary skin infections. Prologue: Topical route is most suitable route for skin infections. The development of topical drug delivery systems designed to have systemic effects appears to be beneficial for a number of drugs on account of the several advantages over conventional routes of drug administration. Methodology: A novel cream formulation consisting of combination of Miconazole nitrate, Mupirocin and Hydrocortisone was prepared. The formulation was subjected to in-vitro diffusion studies. Microbiological studies and in-vivo skin irritation studies were performed to find out the safety of materials used in the formulation. Outcome: The developed cream consisting of combination of Miconazole nitrate, Mupirocin, and Hydrocortisone was found to be safe and effective for the treatment of skin infections.