The effect of Fluvastatin on the inflammatory markers and fibrinolysis analysis in acute myocardial infarction patients

Objective:To observe the effects of different doses of Fluvastatin on the inflammatory markers and fibrinolysis analysis in acute myocardial infarction patients.Method:53 patients with acute myocardial infarction were divided into 2 groups (group A and B).the group A (27 patients) were admitted orally Fluvastatin 40 mg/d and the group B (26 patients) were admitted orally Fluvastatin 80 mg/d.The serum levels of high sensitivity C reactive protein (hs-CRP),soluble CD40 ligand (sCD40L),matrix metalloproteinase-9 (MMP-9) and fibrinolysis analysis were measured at the end of the 3th month and the 6th month.Result:In group A and B,the serum levels of hs-CRP,sCD40L,MMP-9 were significantly decreased at the end of the 3th month and the 6th month (P0.05).And the group B was superior to group A (P0.05).In the groupA there is no significant difference in fibrinolysis analysis after treatment with Fluvastatin (P0.05),but fibrinolysis analysis is significantly different in the group B at the end of the 3th month and the 6th month.Conclusion:The serum level of hs-CRP,sCD40L,MMP-9 were significantly decreased in acute myocardial infarction patients treated with Fluvastatin,and the high dose of Fluvastatin also had anticoagulant effect.