AB1005 Relationship between autoimmunity and osteoporosis in Rheumatoid arthritis

Background Osteoporosis (OP) is more prevalent in patients with rheumatoid arthritis (RA) than in the general population. Positive anti citrullinated peptide antibody (ACPA) has been related with juxta-articular OP, but their relationship with systemic OP in RA is controversial. Objectives To determine if RA autoantibodies (FR and ACPA) are associated with bone mineral density (BMD) in a cohort of patients with established RA diagnosed following the ACR 1987 criteria. Methods Observational study. We analysed the relationship between RF and/or ACPA with the DXA BMD values of the femoral neck (CF) and lumbar spine (LS) (GE LUNAR Prodigy). We perform the analysis using logistic regression, bi and multivariate models, and correlation models. The control variables were sex, body mass, age, duration of RA, prednisone and vitamin D. Results We included 294 patients with RA who had all the tests, with a mean age of 63.4 (±10.9) years and duration of RA of 9.8 (±7.9) years. There were 229 (77.9%) women, 229 (77.9%) positive-RF, 196 (66.7%) positive-ACPA, 109 (37.1%) deficient in 25-OH cholecalciferol ( Conclusions OP was very common in our RA population, especially in women and elderly. Any association was demonstrated between OP and the presence/titer of autoantibodies (RF and ACPA) and low dose of corticosteroids treatment. Disclosure of Interest None declared