The role of chronic gastric ulcer in carcinogenesis

: Results of prolonged conservative treatment of patients with stomach ulcer are analyzed. Two groups of patients have been studied. Group 1 consisted of patients with long-term disease, incidence of stomach cancer in this group was 6.4%. Group 2 consisted of patients operated for stomach cancer and followed-up in cancer dispensary, 12.9% of them had the history of stomach ulcer. Based on anamnesis and results of morphological studies, cases of malignant transformation of chronic gastric ulcer have been revealed. It is demonstrated that prolonged conservative treatment of stomach ulcer in combination with high-grade dysplasia lead to potential risk of malignant transformation. The role of stomach mucosa contamination with herpes viruses was also studied. It is demonstrated that viral contamination is associated with immunodeficiency, maintains chronic inflammation in ulcer and promotes dysplasia progress.