Effect of neoadjuvant chemotherapy on histopathology and immunohistochemistry in breast cancer

Objective: To study effect of neoadjuvant chemotherapy on histopathology and immunohistochemistry in Breast cancer. Methods: Totally 80 breast cancer patients pathologically diagnosed by the core needle biopsy (CNB), received radical operation after neoadjuvant chemotherapy. the morphological changes and immunohistochemical results of ER , PR and HER2 before and after operation were compared. Results: The total effective rate of neoadjuvant chemotherapy on breast cancer is 67.5%, and there was no significant difference of the expression rates of ER, PR and HER2 between pre- and post-operation (P>0.05) but expressions of ER(45.0%), PR(37.5%) and HER2 (12.5%) after operation were discrepancy with those before therapy. Conclusion: Neoadjuvant chemotherapy may be effective to breast cancer, but also helpful to select the appropriate chemotherapy regimens. in other hand, it perhaps interfere with endocrine therapy and targeted therapy for its effect on expression of ER, PR and HER2.