Age and Gender Effects on Chlordiazepoxide Kinetics: Relation to Antipyrine Disposition

Twelve normal subjects aged 24–41 years, and 12 subjects aged 62–79 years, received single 50-mg doses of chlordiazepoxide hydrochloride by mouth and by intravenous injection on two occasions. Chlordiazepoxide volume of distribution was significantly correlated with body weight (r = 0.63, p