Chiral Phosphoric-Acid-Catalyzed Regioselective and Enantioselective C7-Friedel–Crafts Alkylation of 4-Aminoindoles with Trifluoromethyl Ketones

A highly regioselective and enantioselective C7-Friedel–Crafts alkylation of 4-aminoindoles with trifluoromethyl ketones promoted by a spirocyclic phosphoric acid was developed. This strategy was applicable to various substituted trifluoromethyl ketones and 4-aminoindole derivatives, affording the corresponding C7-functionalized indole derivatives, bearing a pharmaceutically interesting trifluoromethylated tertiary alcohol scaffold, in 21%–98% yields with up to >99% enantiomeric excess (ee).