Early mortality after hip fracture surgery in COVID-19 patients: A systematic review and meta-analysis

Objective The aim of this systematic review and meta-analysis was to assess the risk of early mortality in hip fracture patients with COVID-19 infection who undergo surgical intervention Data sources MEDLINE (PubMed) and CINAHL (Cumulative Index to Nursing and Allied Health Literature) databases Study selection Studies were included in the systematic review if they reported postoperative mortality in patients with COVID-19 infection who underwent operative intervention for hip fracture From this selection of studies, only investigations that reported postoperative mortality in a COVID-positive and a non-COVID group were included in the meta-analysis Data extraction Data regarding patient demographics, age, and sex were recorded Additional data that was extracted included study location, data collection period, length of follow-up, COVID testing methodology, COVID testing results, and number of patients who underwent operative versus nonoperative management The primary outcome of interest was postoperative mortality Data synthesis Random effects meta-analyses were performed to assess the pooled relative risk of postoperative mortality according to COVID status Odds ratios and 95% confidence intervals (CI) were calculated Conclusions The overall pooled mortality rate in the early postoperative period for hip fracture patients with concomitant COVID-19 infection was 32 6% The relative risk for postoperative mortality in COVID-positive patients compared to non-COVID patients was 5 66 (95% CI 4 01–7 98;p < 0 001) The currently available literature demonstrates that COVID-19 infection represents a substantial risk factor for early postoperative mortality in the already susceptible hip fracture population Further investigations will be needed to assess longer-term morbidity and mortality in this patient population Level of evidence Therapeutic Level IV