Integrative analysis of microRNA and mRNA expression profiles in osteosarcoma cell lines

The aim of this study was to provide a comprehensive analysis of the role microRNA deregulation might play in osteosarcoma pathogenesis. Osteosarcoma cell lines were analyzed for genome wide microRNA and mRNA expression. Additionally the cell lines were characterized phenotypically using in vitro cell assays. By this means, deregulated microRNA and their potential target genes significantly correlating with the osteosarcoma cell lines’ potential to proliferate, migrate and invade were found. Moreover, microRNA and mRNA differentially expressed in osteosarcoma versus progenitor cell lines (using human osteoblasts and mesenchymal stem cell lines as references) have been identified.