Asymmetric Periflexural Exanthem In Childhood

Asymmetric periflexural exanthem of childhood (APEC) is a dermatosis that was first described in 1962 by Brunner et al. as ''a new papular erythema''.[1] In 1986, Taieb et al. also described this disease, then suggested the term APEC in a second publication in 1993.[2] APEC is a distinctive and a self-limited exanthem which classically affects children and less frequently adults [3]. The precise etiology of this condition is unknown, but the hypothesis of a viral cause seems to be plausible but remains unconfirmed. APEC manifests as a unilateral papular exanthem with stereotypical morphology and distribution. Usually, laboratory investigations and biopsy are not necessary for this condition because of its excellent prognosis and its self-limited character in a few weeks.