6-Phenyl-6-alkylamido-5,6-dihydro-2H-pyran-2-ones: Novel HIV Protease Inhibitors.
2010
Abstract Publications from our laboratories have recently described a series of 3-thioaryl substituted-4-hydroxy-pyrones1 as HIV protease inhibitors. The current work examines the analogous 5,6-dihydro-2H-pyran-2-ones with 6,6-substitutions focusing on the use of 1°, 2°, and 3° alkyl amides of various chain lengths to fill the S1 through S3 enzyme pockets.
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