Frequency of rare cytogenetic abnormalities at relapse in acute myeloid leukemia (AML) with FLT3 internal tandem duplication (ITD) and normal karyotype at diagnosis: Evidence for genomic instability?

Theodore Stewart Gourdin,Yi Ning,Feyruz V. Rassool,Michael L. Tidwell,Vu H. Duong,Ashkan Emadi,Maria R. Baer

Frequency of rare cytogenetic abnormalities at relapse in acute myeloid leukemia (AML) with FLT3 internal tandem duplication (ITD) and normal karyotype at diagnosis: Evidence for genomic instability?

2017

Theodore Stewart Gourdin
Yi Ning
Feyruz V. Rassool
Michael L. Tidwell
Vu H. Duong
Ashkan Emadi
Maria R. Baer

7049 Background: FLT3-ITD mutations are present in AML in 30% of patients, most commonly with a normal karyotype, and are associated with short disease-free survival. In vitro and in vivo studies o...

Keywords:

Karyotype
Genome instability
In vivo
Pathology
FLT3 Internal Tandem Duplication
In vitro
Medicine
Myeloid leukemia

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