Therapeutic Effects of Tetramethypyrazine on Acute Respiratory Distress Syndrome in Rat Model Induced by Lleic Acid

Objective:To study the therapeutic effects of tetramethypyrazine(TMP)on acute respiratory distress syndrome(ARDS)in rat model induced by oleic acid.Methods:The rat model with ARDS was estabˉlished by the intravenous infusion of oleic acid.Before and after the therapy,the ratio of6-keto-PGF1α/thromboxane B 2 (TXB 2 )and the level of MDA in lung tissues were measured.The pathological changes in lung tissues were examined by light microscope.Results:By the therapy of TMP,the ratio of6-keto-PGF1α/TXB 2 was enhanced and the level of MDA was decreased.The pathological changes were improved and the mortality of rat model was decreased.Conclusion:The TMP has the therapeutic effects on ARDS in rat model induced by oleic acid.