Interactions of the neuro-immune-stromal triad in itch.

This prospective focuses on recent advances in understanding of the mechanisms involved in itch signaling in the skin and how these new findings fit into the wider picture of the expression of itch mediators and their receptors in the dermal layer. Since, at present, studies mostly concentrate on single cellular compartments (e.g. neural alone), we suggest that they may miss important interactions with other compartments. Therefore, we propose that studies, in order to fully appreciate pruritus, should consider (e.g., by using transcriptomic information) signal transmission within the entire neuro-immune-stromal triad.