Phyto-composition and antimicrobial activities of the ethanol seed extracts of Buchholzia coriacea

Background: There is a growing awareness in correlating phytochemical compounds with their biological activities. Folk medicines suggest that Bulccholzia coriacea is effective in the management of bacterial infections. Objectives: This research was aimed at investigating the phyto-composition and antimicrobial activities of Bulccholzia coriacea ethanol seed extract. Methods: Phyto-composition of Bulccholzia coriacea seeds were determined using gas chromatography mass spectroscopy (GC-MS) technique. Clinical isolates; Staphylococcus aureus, Staphylococcus epidermidis, Pseudomonas aeruginosa, Klebsiella pneumonia , Streptococcus faecalis, and Candida albicans were used to test for the antimicrobial activities of Bulccholzia coriacea seeds following disc diffusion and broth dilution methods. Results: Gas chromatogram reveal six peaks depicting different phyto-constituents with Oleic acid (75.57%) highest peaked. Candida albican, Staphylococcus epidermidis, Klebsiella pneumonia and Staphylococcus aureus had the same minimum inhibitory concentration (MIC) value of 6.25mg/ml and minimum bactericidal concentration (MBC) value of 12.5mg/ml. Conclusion: Findings from this study supports the claims of local people who use B. coriacea seeds for the management of infectious diseases. Keywords : Phyto-composition; antimicrobial; Buchholzia coriacea