Sebaceous carcinoma associated with seborrheic keratosis.
2010
Background: The association of a seborrheic keratosis with other common cutaneous neoplasms such as basal cell carcinoma and Bowen disease has been reported, but the association between a seborrheic keratotis and a malignant neoplasm with sebaceous differentiation is very unusual. Objective: We present a case of two contiguous neoplasms, a seborrheic keratosis and a sebaceous carcinoma, and discuss the possibility of malignant change in a seborrheic keratosis as an explanation for the findings. Methods and Results: A 57-year-old man presented with an asymptomatic tumor on the skin of his abdomen that was composed of two separate but contiguous lesions. The central lesion, about 0.9 cm in diameter, was nodular, irregular, and reddish and was surrounded by a blackish lesion about 3 cm in greatest dimension. Histopathologic examination revealed that the plaque was composed of two different adjacent tumors, including a central portion showing findings consistent with a sebaceous carcinoma and a peripheral part showing a seborrheic keratosis. Conclusion: Although the association is likely to be a coincidence and probably represents a collision tumor, the possibility that the sebaceous carcinoma represents malignant degeneration of the seborrheic keratosis cannot be entirely excluded. Antecedents: On a rapporte des cas de keratoses seborrheiques en presence d'autres neoplasmes cutanes repandus, tels que les carcinomes basocellulaires et la maladie de Bowen, mais les cas de keratoses seborrheiques en presence d'un neoplasme malin a differentiation sebacee sont tres inusuels. Objectif: Presenter le cas de deux neoplasmes contigus, une keratose seborrheique et un carcinome sebace, et discuter des possibilites de mutation maligne dans la keratose seborrheique pour expliquer ce phenomene. Methodes et resultats: Un homme de 57 ans s'est presente avec une tumeur cutanee asymptomatique au niveau de l'abdomen, composee de deux lesions contigues distinctes. La lesion centrale, mesurant environ 0,9 cm de diametre, etait nodulaire, irreguliere, et rougeâtre, entouree d'une lesion noirâtre d'environ 3 cm dans sa partie la plus large. L'examen histopathologique a revele qu'il s'agissait en fait de deux tumeurs distinctes adjacentes, dont une partie centrale correspondant a un carcinome sebace et une partie peripherique constituee d'une keratose seborrheique. Conclusion: Bien que cette association soit probablement une coincidence representant une association de deux tumeurs a histologie differente, la possibilite que le carcinome sebace represente une degenerescence maligne de la keratose seborrheique ne peut pas etre totalement exclue.
Keywords:
- Correction
- Source
- Cite
- Save
- Machine Reading By IdeaReader
18
References
4
Citations
NaN
KQI