Solid-support synthesis of natural product-like compounds derived from D-(-)-ribose

The synthesis of natural product-like compounds on solid support is described. Starting from a readily accessible D-(-)-ribose derivative, a tricyclic scaffold is prepared in five steps. After coupling onto solid supportsbearing different substituents (PAL resins), the scaffold can be further derivatised at two diversity points. Representative derivatives obtained by this diversity-oriented procedure are described.