ОЦЕНКА ЭФФЕКТИВНОСТИ ВЛИЯНИЯ ИНФЛИКСИМАБА НА ПРОВОСПАЛИТЕЛЬНУЮ ЦИТОКИНЕМИЮ И НАРУШЕНИЯ УПРУГО-ЭЛАСТИЧЕСКИХ СВОЙСТВ СОСУДИСТОГО РУСЛА У БОЛЬНЫХ ПСОРИАТИЧЕСКИМ АРТРИТОМ

76 patients with psoriatic arthritis high and middle disease activity were determined according concentration of proinfl ammatory cytokines (interleukin -1β (IL-1β), Interleukin – 6 (IL-6), soluble interleukin– 6 receptor (sIL6r), IL-6r tumor necrosis factor – α (TNF- α), C-reactive protein (CRP)) and some parameters of elasticity of vessel wall (AIx, ASI indexes). It was found out the increased concentration of proinfl ammatory cytokines (IL-1β, sIL-6r, IL-6, TNF- α), CRP and increased rigidity of vessel wall (increased speed of pulse wave spreading – SPWS), and decrease elasticity of vessel wall (increased indexes AIx, ASI). In psoriatic arthritis patients. There was a signifi cant association between the levels of proinfl ammatory cytokines, SPWS, and AIx, ASI indexes. Infl iximab – treated patients during 50 weeks demonstrated except good clinical response decreased levels of proinfl ammatory cytokines and increased elasticity of vessel. Rhere was a signifi cant association between the levels of proinfl ammatory cytokines, SPWS and AIx, ASI indexes.