Differences in the Signaling Pathways of α1A- and α1B-Adrenoceptors Are Related to Different Endosomal Targeting

Vanessa Segura,Miguel Perez-Aso,Fermí Montó,Elena Carceller,M.A. Noguera,John D. Pediani,Graeme Milligan,Ian McGrath,Pilar D’Ocon

Differences in the Signaling Pathways of α1A- and α1B-Adrenoceptors Are Related to Different Endosomal Targeting

2013

Vanessa Segura
Miguel Perez-Aso
Fermí Montó
Elena Carceller
M.A. Noguera
John D. Pediani
Graeme Milligan
Ian McGrath
Pilar D’Ocon

Aims To compare the constitutive and agonist-dependent endosomal trafficking of α1A- and α1B-adrenoceptors (ARs) and to establish if the internalization pattern determines the signaling pathways of each subtype.

Keywords:

Endosome
Transport protein
Endocytosis
Lipid signaling
Internalization
Signal transduction
HEK 293 cells
Biology
Calcium signaling
Cell biology

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