Anthelmintic activity of transition metal complexes of some benzamides

Copper and cobalt complexes of four benzamides, [N-(3’-nitrophenyl) (piperidin-1"-yl) methyl] benzamide, [N (piperidin1"-yl) (p-tolyl ) methyl] benzamide, [N-(4’ – chloro - phenyl) (piperidin-1"-yl) methyl] benzamide and [N- (4’-methoxy- phenyl) (piperidin-1"-yl] benzamide have been synthesized. Anthelmintic activity of benzamides and their complexes have been evaluated against Indian Earth worm species Eicinia foetida. The results reveal a dose dependent increase in activity of the compounds at 5, 10 and 20 mg/ml concentration. All the metal complexes exhibit significant activity in dose dependant manner. Both cobalt and copper complexes are found to be more active as compared to ligand and standard drug albendazole.