The Correlation Study of Coronary Slow Flow and Endothelial Function Injury

Objective To investigate the relationship between endothelial dysfunction and pathogeny of coronary slow flow(CSF) by observing the plasma nitric oxide(NO) and endothelin-1(ET-1)levels of CSF patients.Methods Eighty-five patients with normal coronary flow and angiographically normal coronary arteries were enrolled as control group,and 85 patients with coronary slow flow angiographically were enrolled as CSF group.The stenosis group population consisted of 85 patients with coronary artery stenosis angiographically.Coronary flow patterns of the cases were assessed by corrected thrombolysis in myocardial infarction(TIMI) frame count(CTFC).The changes of plasma NO and ET-1 were measured respectively.Results Slow flow and stenosis group the plasma levels of ET-1 were higher than the control group,the difference was statistically significant(P0.05);slow flow of plasma ET-1 below the stenosis group,the difference was statistically significant(P0.01).Slow flow and stenosis group the plasma levels of NO were lower than the control group,the difference was statistically significant(P0.01);slow flow of plasma NO is higher than that of stenosis group,the difference was statistically significant(P0.01).Slow flow and stenosis group and low density lipoprotein cholesterol,blood uric acid level and the proportion of smokers was higher than that of the control group,the control group was higher than that of high density lipoprotein slow blood flow and stenosis group,the differences were statistically significant(P0.05).Multivariate Logistic regression analysis showed that,ET-1 increased,NO decreased,increased,low density lipoprotein,high density lipoprotein,reduce blood uric acid increased,and smoking as independent risk factors for CSF.Conclusion High uric acid level,high LDL-C level,low HDL-C level and smoking play an important role in the pathogenesis of CSF.A significant correlation between CSF and impaired endothelial function was found in this study.