Effects of Cyclic Cryotherapy system on the improvement after total knee arthroplasty: a systematic review

Objective To evaluate the clinical effects of Cyclic Cryotherapy system on early symptoms after total knee arthroplasty (TKA) . Methods The randomized controlled trial (RCT) articles on Cyclic Cryotherapy system after TKA were retrieved from Cochrane Library, JBI, PubMed, Web of Science, EBSCO, CNKI, Wanfang database and China Biology Medicine disc (CBMdisca) , with the time limitation from the establishment of the database to 31st May 2018. Two researchers screened the literature according to the criteria of inclusion and exclusion, extracted the data, and used RevMan 5.3.3 software for statistical analysis. Results A total of 12 studies (976 cases) were included. The results of Meta analysis showed that, comparing between the Cyclic Cryotherapy and ice pack, the differences on pain score 24 hours after operation [MD=-0.70, 95%CI (-0.97, -0.43) , P<0.000 01], volume of drainage 48 hours after operation [MD=-143.04, 95%CI (-166.51, -119.57) , P<0.000 01]and swelling 1 week after operation [MD=-0.22, 95%CI (-0.32, -0.13) , P<0.000 01]were all statistically significant. Conclusions The existing evidence shows that compared with the ice pack, the Cyclic Cryotherapy system has the advantages of early postoperative analgesia, hemostasis, later detumescence, promoting recovery, improving comfort and no adverse reactions of cryotherapy. Key words: Meta analysis; Arthroplasty, replacement, knee; Cyclic Cryotherapy system; Total knee arthroplasty; Symptoms improvement; Systematic review