Neurobehavioral effects of vigabatrin and its ability to induce DNA damage in brain cells after acute treatment in rats
2017
Rationale
Vigabatrin (VGB) is a drug indicated mostly for the treatment of spasms in childhood and West’s syndrome patients. This drug inhibits irreversibly the enzyme GABA-transaminase (GABA-T), increasing GABA concentrations and enhancing GABAergic neurotransmission in the brain, which is known to induce behavioral changes.
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