Pharmacokinetics of lamotrigine in paediatric and young adult epileptic patients—nonlinear mixed effects modelling approach

Branka Brzaković,Katarina Vučićević,Sandra Vezmar Kovačević,Branislava Miljković,Milica Prostran,Žarko Martinović,M. Pokrajac

Pharmacokinetics of lamotrigine in paediatric and young adult epileptic patients—nonlinear mixed effects modelling approach

2014

Branka Brzaković
Katarina Vučićević
Sandra Vezmar Kovačević
Branislava Miljković
Milica Prostran
Žarko Martinović
M. Pokrajac

Purpose The purpose of the study was to examine and describe adjunctive lamotrigine (LTG) pharmacokinetics in paediatric and young adult patients using a nonlinear mixed effects modelling (NONMEM) approach.

Keywords:

Anesthesia
Therapeutic drug monitoring
Medicine
Young adult
Intensive care medicine
Lamotrigine
NONMEM
Pharmacokinetics
pharmacology toxicology
Diabetes mellitus
mixed effects

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