Biochemical recurrence of prostate cancer after radical prostatectomy

Prostate cancer is the second cancer in frequency of occurrence in developed countries in men older than 50 years. In Europe, as the cause of death in men, prostate cancer is the second right after lung cancer. Annually from the disease, which is the second death in men in Macedonia, affects about 70 new patients, and even 90% of them are detected at a late stage when complete cure of the patient is almost impossible. In R.Macedonia annually only 20 patients are with early diagnosed prostate cancer. One of the ways to cancer recurrence after radical prostate initial treatment ( RT or RP) is biochemical relapse. Men who suffer biochemical recurrence following RP can be divided into three groups: 1. Persistent disease; 2.Recurrent disease and 3.The case with persistent but low PSA levels attributed to slow PSA metabolism or residual binign tissue. The question is : What to do and when to act in patients with biochemical recurrence after RP for clinically and pathologically apparent metastatic disease?